INOSITOL PYROPHOSPHATE AND UBIQUITIN-PROTEASOMAL PATHWAYS REGULATE CELL SIGNALING AND METABOLISM

Author

• Hector Mora

Date of Award

2015

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Chakraborty, Anutosh

Abstract

The prevalence of obesity and type-2 diabetes (T2D) related comorbidities in the US emphasize the need for their treatment. Enzymes implicated in these diseases are favorable targets due to their specific catalytic activity. The Chakraborty lab discovered that inositol hexakisphosphate kinase-1 (IP6K1), an enzyme that synthesizes the signaling inositol pyrophosphate IP7, promotes fat accumulation and insulin resistance. Thus, IP6K1 is a novel target in obesity/T2D. However, how IP6K1 expression, stability, and activity are modulated in vivo remains unknown. Recent experiments establish that IP6K1 interacts with a novel ubiquitin ligase, Ube4A. Studies are ongoing to determine the cellular role of Ube4A as well as the physiological consequences of IP6K1-Ube4A interaction.

Comments

Includes bibliography.

Recommended Citation

Mora, Hector, "INOSITOL PYROPHOSPHATE AND UBIQUITIN-PROTEASOMAL PATHWAYS REGULATE CELL SIGNALING AND METABOLISM" (2015). Harriet L Wilkes Honors College Theses 2010 - 2019. 208.
https://digitalcommons.fau.edu/etd_honors_2/208

Extent

38 p.

Identifier

FA00013651