Date of Award
Spring 5-2025
Document Type
Thesis
Publication Status
Version of Record
Submission Date
November 2026
College Granting Degree
Harriet L. Wilkes Honors College
Thesis/Dissertation Advisor [Chair]
Samantha McGovern
Abstract
The pro-inflammatory cytokine interleukin-1 (IL-1) has diverse functions within the brain such as facilitating memory and regulating sleep, yet is linked to various psychopathological disorders including depression, anxiety, and PTSD. The IL-1 type 1 receptor (IL-1R1) is the sole receptor of IL-1 and is predominantly expressed on non-neuronal cell types in the brain; however, the existence of IL-1R1 on neurons has been debated due to inconsistent mapping attempts. Here, we generated a specific atlas of neuronal IL-1R1 (nIL-1R1) distribution throughout the brain in global and glutamatergic-neuron-specific IL-1R1 reporter mice. Using immunohistochemical labeling and the QUINT workflow, we show nIL-1R1 is primarily found in brain regions related to sensory processes. Further, we directly stimulated nIL-1R1 with intracerebroventricular IL-1 injections to investigate the receptor’s activity. Our results expand the knowledge on the cytoarchitecture of brain nIL-1R1 and kinetics of the receptor’s responsiveness, which could be crucial for understanding IL-mediated neuroinflammatory disorders.
Recommended Citation
Maxey, Gabriella, "Whole-Brain Mapping of Neuronal Interleukin-1 Tpe 1 Receptor in the Mouse Brain" (2025). Harriet L Wilkes Honors College Theses 2020 - Present. 274.
https://digitalcommons.fau.edu/etd_honors/274