Date of Award

2022

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Duboué, Erik R.

Abstract

Sleep deprivation (SD) is an extremely common problem worldwide. SD is correlated with various psychological and physiological consequences, such as mood instability or somatic pain, and it has also been linked to increased stress. While the relationship between stress and SD is well-studied, little is known about the neuronal mechanism underlying this relationship. Sleep-regulating (SL) pathways and stress-regulating (ST) pathways are both modulated by the circadian rhythm, and there are interactions between the two—some regions that contribute to sleep regulation also contribute to stress regulation. Sleep inhibits the activation of the HPA-axis, an ST system. SD results in a disruption in the SL systems, which subsequently disrupts ST systems. Three mechanisms underlying how SD leads to increased stress includes: 1. decreased inhibition of the HPA-axis, 2. ultradian rhythm dysregulation resulting in dysregulated stress response and 3. activation of other stress-responding regions.

Comments

Thesis (B.S.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2022

Extent

77 p.

Identifier

FAUHT00185

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