Date of Award
2013
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Abstract
Finding novel compounds that affect neuronal or muscular function is of great interest, as they can serve as potential pharmacological agents for a variety of neurological disorders. For instance, conopeptides have been developed into powerful drugs like the painkiller PrialtTM. Most conopeptides, however, have yet to be characterized, revealing the need for a rapid and straightforward screening method. We have designed a novel bioassay, which allows for unbiased screening of biological activity of compounds in vivo against numerous molecular targets on a wide variety of neurons and muscles in a rapid and straightforward manner. For this, we paired nanoinjection of compounds with electrophysiological recordings from the Giant Fiber System of Drosophila melanogaster, which mediates the escape response of the fly.
Extent
xv,148 p. : ill. (some col.)
Recommended Citation
Mejia, Monica, "Development of a novel assay for in vivo screening of neuromodulatory drugs and targeted disruption of cholinergic synaptic transmission in Drosophila melanogaster" (2013). Electronic Theses and Dissertations 2010 - 2019. 736.
https://digitalcommons.fau.edu/etd_general_6/736
Identifier
FADT3362560
Comments
by Monica Mejia.|Thesis (Ph.D.)--Florida Atlantic University, 2013.|Includes bibliography.|Mode of access: World Wide Web.|System requirements: Adobe Reader.|by Monica Mejia.