Date of Award
2012
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Abstract
Cytogenetics is a study on the genetic considerations associated with structural and functional aspects of the cells with reference to chromosomal inclusions. Chromosomes are structures within the cells containing body's information in the form of strings of DNA. When atypical version or structural abnormality in one or more chromosomes prevails, it is defined as chromosomal aberrations (CA) depicting certain genetic pathogeny (known as genetic disorders). The present study assumes the presence of normal and abnormal chromosomal sets in varying proportions in the cytogenetic complex ; and, stochastical mixture theory is invoked to ascertain the information redundancy as a function of fractional abnormal chromosome population. This bioinformatic measure of redundancy is indicated as a track-parameter towards the progression of genetic disorder, for example, the growth of cancer. Lastly, using the results obtained, conclusions are enumerated, inferences are outlined and directions for future studies are considered.
Extent
xii, 108 p. : ill. (some col.)
Recommended Citation
Karri, Jagadeshwari., "Cytogenic bioinformatics of chromosomal aberrations and genetic disorders" (2012). Electronic Theses and Dissertations 2010 - 2019. 485.
https://digitalcommons.fau.edu/etd_general_6/485
Identifier
FADT3358597
Comments
by Jagadeshwari Karri.|Thesis (M.S.C.S.)--Florida Atlantic University, 2012.|Includes bibliography.|Mode of access: World Wide Web.|System requirements: Adobe Reader.|by Jagadeshwari Karri.