Date of Award
2011
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Abstract
Sjèogren's syndrome (S) is a chronic autoimmune disease characterized by ocular and oral dryness and primarily affects post menopausal women. In the present study we investigated the time course of lymphocytic infiltration, apoptosis, caspase-3 activity and different cytokines levels in the lacrimal glands of both genetically predisposed and control mice to elucidate immunopathological mechanism leading to dry eye. The results of our experiments showed that ovariectomy accelerated pathological findings of SS by increasing lympocytic infiltration, cytokine production, lacrimal gland cell death and cleaved caspase-3 activity, and these effects were more pronounced and persistent in the genetically predisposed mouse model of SS. In addition, we observed that lymphocytic infiltration occurred earlier compared to apoptosis which may perpetuate immune mediated destruction of lacrimal epithelial cells. Furthermore, treatment with physioloigical doses of 17-B Estradiol (E2) or DIhydrotestosterone (DHT) prevented all these pathological events observed after ovariectomy.
Extent
xii, 85 p. : ill. (some col.)
Recommended Citation
Mostafa, Safinaz, "Influence of sex hormones and genetic predisposition in dry eye in Sjèogren's syndrome" (2011). Electronic Theses and Dissertations 2010 - 2019. 310.
https://digitalcommons.fau.edu/etd_general_6/310
Identifier
FADT3353086
Comments
by Safinaz Mostafa.|Thesis (M.S.)--Florida Atlantic University, 2011.|Includes bibliography.|Electronic reproduction. Boca Raton, Fla., 2011. Mode of access: World Wide Web.|by Safinaz Mostafa.